Preparation and Root Growth-Modulatory Activity of N-Substituted 2-Acetylamino-2-ethoxycarbonyl-3-(2-furyl)propanamides.
-
- KITAGAWA Tokujiro
- Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
-
- AKIYAMA Naohiro
- Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
-
- MASAI Katsunori
- Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
この論文をさがす
抄録
N-Substituted 2-acetylamino-2-ethoxycarbonyl-3-(2-furyl)propanamides (8) were synthesized through the reaction of amines (13) with 2-acetylamino-2-ethoxycarbonyl-3-(2-furyl)propanoic acid (3b), which was prepared via condensation of 2-(bromomethyl)furan (10b) with diethyl acetamidomalonate, followed by partial hydrolysis of the resultant diethyl ester (3a) in the presence of barium hydroxide. However, bulky amines such as tert-butyl-amine or 2-trifluoromethylaniline did not afford the corresponding diamides (8). The biological activity of the prepared diamides (8) as root growth modulators was examined by germination assay using rape and leek seeds. N-(5-Bromo-2-thiazolyl)- and N-(4-chloro-2-benzothiazolyl)-2-acetylamino-2-ethoxycarbonyl-3-(2-furyl)propanamides (8h, i) both potently inhibited the root growth of rape seedlings, but were less effective in the case of leek seeds. The herbicide 2, 4-dichlorophenoxyacetic acid completely inhibited root growth in both cases.
収録刊行物
-
- CHEMICAL & PHARMACEUTICAL BULLETIN
-
CHEMICAL & PHARMACEUTICAL BULLETIN 49 (3), 335-339, 2001
公益社団法人 日本薬学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001204160961664
-
- NII論文ID
- 110003615899
-
- NII書誌ID
- AA00602100
-
- COI
- 1:CAS:528:DC%2BD3MXhs1Ohtr4%3D
-
- ISSN
- 13475223
- 00092363
-
- NDL書誌ID
- 5683151
-
- PubMed
- 11253928
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可