Improved Preparation of Sulfur Substituted 3-Vinylpyrrole and Its Application to the Syntheses of Chuangxinmycin Derivatives

Abstract

Sulfur substituted 3-vinylpyrrole 10 was prepared from 3-thio-acetylpyrrole 9 by alkylation with alkyl halide in the presence of propylene oxide. Functionalized 4-alkylthioindoles were made by Diels-Alder reaction of the 3-vinylpyrrole 10 with dienophiles. Chuangxinmycin analogues were synthesized by using some of the functionalized 4-alkylthioindoles as key intermediates.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 49(9), 1198-1202, 2001-09-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  15

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Codes

  • NII Article ID (NAID) :
    110003616076
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    NOT
  • ISSN :
    00092363
  • NDL Article ID :
    5893008
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.49.1198
  • Databases :
    CJP  NDL  NII-ELS  J-STAGE 

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