Cytotoxic Alkaloids and a Flavan from the Bulbs of Crinum asiaticum var.japonicum

    • MIN Byung Sun
    • Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
    • GAO Jiang Jing
    • Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
    • NAKAMURA Norio
    • Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
    • HATTORI Masao
    • Institute of Natural Medicine, Toyama Medical and Pharmaceutical University

Abstract

A new pyrrolophenanthridone alkaloid, criasiaticidine A (1), was isolated from the bulbs of Crinum asiaticum var.japonicum, together with pratorimine (2), lycorine (3) and 4'-hydroxy-7-methoxyflavan (4). The structure of the new alkaloid was determined to be 4, 5-etheno-9, 10-dihydroxy-6-phenanthridone by spectroscopic means. The cytotoxicity of the isolated compounds 1-4 was evaluated in vitro against Meth-A (mouse sarcoma) and Lewis lung carcinoma (mouse lung carcinoma) tumor cell lines. Furthermore, 3 was examined for in vivo antitumor activity with LLC tumor cells.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 49(9), 1217-1219, 2001-09-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  26

You must have a user ID to see the references.If you already have a user ID, please click "Login" to access the info.New users can click "Sign Up" to register for an user ID.

Cited by:  1

You must have a user ID to see the cited references.If you already have a user ID, please click "Login" to access the info.New users can click "Sign Up" to register for an user ID.

Preview

Preview

Codes

  • NII Article ID (NAID) :
    110003616081
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    Journal Article
  • ISSN :
    00092363
  • NDL Article ID :
    5893093
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.49.1217
  • Databases :
    CJP  CJPref  NDL  NII-ELS  J-STAGE 

Share