Potensial Insulinominetic Agents of Zink(2) Complexes with Picolinamide Derivatives--Preparations of Complexes,in Vitro and in Vivo Studies

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  • Ueda Eriko
    Department of Chemistry, Graduate School of Science, Osaka City University
  • Yoshikawa Yutaka
    Department of Chemistry, Graduate School of Science, Osaka City University
  • Ishino Yoshio
    Department of Organic Chemistry, Osaka Municipal Technical Research Institute
  • Sakurai Hiromu
    Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University
  • Kojima Yoshitane
    Department of Chemistry, Graduate School of Science, Osaka City University

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タイトル別名
  • Potential Insulinominetic Agents of Zinc(II) Complexes with Picolinamide Derivatives: Preparations of Complexes, in Vitro and in Vivo Studies.
  • Potential insulinomimetic agents of zinc(II) complexes with picolinamide derivatives: preparations of complexes, in vitro and in vivo studies

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Following the finding of in vitro insulinominetic activities of new prepared Zn(II) complexes with amide ligands (2-picolinamide (pa-a) and 6-methyl-2-picolinmethylamide (6mpa-ma)) in isolated rat adipocytes treated with epinephrine in terms of inhibition of free fatty acid release, their blood glucose normalizing effects were observed on daily intraperitoneal injections for 14 d in a type 2 diabetes mellitus model animal, KK-Ay mice. The blood glucose levels of KK-Ay mice were maintained in a normal range during the administration of both complexes. After the administration of each complex for 14 d, the improvement of glucose metabolism was confirmed as judged by the glucose tolerance test.

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