Triterpenes from the Spores of Ganoderma lucidum and Their Inhibitory Activity against HIV-1 Protease

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抄録

Two new lanostane-type triterpenes, lucidumol A and ganoderic acid β, were isolated from the spores of Ganoderma (G.) lucidum, together with a new natural one and seven that were known. The structures of the new triterpenes were determined as (24S)-24,25-dihydroxylanost-8-ene-3,7-dione and 3β, 7β-dihydroxy-11,15-dioxolanosta-8,24(E)-dien-26-oic acid, respectively, by chemical and spectroscopic means. The quantitative analyses of 5 fruiting bodies, antlered form and spores of G. lucidum were performed by high performance liquid chromatography and demonstrated that ganoderic alcohol and acid contents were quite high in the spore. Of the compound isolated, ganoderic acid β, (24S)-lanosta-7,9(11)-diene-3β, 24,25-triol (called lucidumol B), ganodermanondiol, ganodermanontriol and ganolucidic acid A showed significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC_<50> values of 20-90 μM.

収録刊行物

  • Chemical & pharmaceutical bulletin

    Chemical & pharmaceutical bulletin 46(10), 1607-1612, 1998-10-15

    公益社団法人日本薬学会

参考文献:  33件中 1-33件 を表示

被引用文献:  12件中 1-12件 を表示

各種コード

  • NII論文ID(NAID)
    110003616765
  • NII書誌ID(NCID)
    AA00602100
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00092363
  • NDL 記事登録ID
    4585756
  • NDL 雑誌分類
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL 請求記号
    Z53-D167
  • データ提供元
    CJP書誌  CJP引用  NDL  NII-ELS 
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