Synthesis and in Vitro Antiprotozoal Activity of Thiophene Ring-Containing Quinones.

• VALDERRAMA Jaime

• FOURNET Alain

• VALDERRAMA Claudio

• BASTIAS Sandra

• ASTUDILLO Claudio

• ROJAS DE ARIAS Antonieta

• INCHAUSTI Alba

• YALUFF Gloria

抄録

A series of quinones (3a-i, 4-9, 11) and aromatic compounds (2a, 2b, 2g) containing the thiophene ring were tested in vitro against the trypomastigote form of Trypanosoma cruzi and the promastigote forms of Leishmania. The quinones 3a-i, 4, 5a, b, 6 and 9 having the thiophene ring fused to a quinone nucleus were the most active members of the series. The electron affinities of the benzo[b]thiophene-4, 7-quinones 3, evaluated by their LUMO energies and halfwave potentials, are reported.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 47 (9), 1221-1226, 1999

  公益社団法人 日本薬学会

キーワード

• benzo[b]thiophene-4, 7-quinones
• synthesis
• biological activity
• Leishmania
• Trypanosoma cruzi
• electron affinity

詳細情報

• CRID: 1390282679140510976
• NII論文ID: 130003947946
• NII論文ID: 110003617404
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.47.1221
• COI: 1:CAS:528:DyaK1MXmtFCmsrs%3D
• ISSN: 13475223
• ISSN: 00092363
• ISSN: http://id.crossref.org/issn/00092363
• NDL書誌ID: 4856781
• PubMed: 10517004
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4856781
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/47/9/47_9_1221/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可