Detoxication and Excretion of Radioactive Strontium. IV. Effect of Sodium Calcium Citrate and the Mode of Action of Citrate.

• 伊藤 四十二

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 鶴藤 丞

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 色田 幹雄

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 石橋 貞彦

  Faculty of Pharmaceutical Sciences, University of Tokyo

抄録

After the injection of radioactive strontium, a mixture of trisodium citrate and monosodium monocalcium citrate was injected into rats and the effect of monosodijm monocalcium citrate injection in accelerating the excretion of radiostrontium was compared with the effect of the injection of trisodium citrate only. Greatly enhanced excretion of radiostrontium into urine was found in the rats treated with sodium calcium citrate, without any symptom of hypocalcemia. When citrate was injected into rats in the form of either trisodium salt or sodium calcium salt, citrate level in blood plasma was greatly elevated and nearly one-half of injected citrate was found in the urine within six hours. Mechanism of the action of citrate on the excretion of radioactive strontium is discussed and attributed to its chelating ability.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 6 (3), 287-290, 1958-06-20

  公益社団法人日本薬学会

詳細情報

• CRID: 1571980077375719424
• NII論文ID: 110003617976
• NII書誌ID: AA00602100
• ISSN: 00092363
• 本文言語コード: en
• データソース種別:
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