The Preparative and Pharmacological Studies of levo and dextro 9-Aza-des-N-morphinan (2, 3, 4, 4a-Tetrahydro-1H, 6H-5, 10b-propanophenanthridin-9-ol).
Bibliographic Information
- Other Title
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- The preparative and pharmacological studies of levo and dextro 9-aza-des-N-morphinan(2,3,4,4α-tetrahydro-1H,6H-5,10b-propanophenanthridin-9-01)
- The preparative and pharmacological studies of levo and dextro 9-aza-des-N-morphinan 2 , 3 , 4 , 4 アルファ-tetrahydro-1H , 6H-5 , 10b-propanophenanthridin-9-01
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Abstract
The analgesic effect was found in levo-isomer (DH-15) of 2, 3, 4, 4a-tetrahydro-1H, 6H-5, 10b-propanophenanthridin-9-ol, but not in dextro-isomer (DH-14). The analgesic effect of DH-15 was some what stronger than morphine, synergistic to morphine and antagonized by Levallorphane. The acute toxicity of DH-15 was far stronger than that of morphine. The pharmacological effects of DH-15 on the body temperature of mice and rats, barbiturate anaesthesia in mice, purpil of mice and gastrointestinal propulsion in mice were similar to that of morphine, but less active except barbiturate anaesthesia. DH-14 showed little effects. The contraction or increase of tonus in the isolated or in situ intestine of rabbits by the low dosis of DH-14 and DH-15 were observed.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 11 (4), 489-494, 1963
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204168387584
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- NII Article ID
- 110003619118
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- NII Book ID
- AA00602100
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- COI
- 1:CAS:528:DyaF3sXksVyht7c%3D
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- ISSN
- 13475223
- 00092363
- http://id.crossref.org/issn/00092363
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- NDL BIB ID
- 9245214
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- PubMed
- 13953263
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed