Studies on the Pyrimidine Derivatives. XXXI. Reactions of Ethyl 2-Methoxymethylene-3-ethoxypropionate with Ureas

• 高見沢 映

• 平井 健太郎

抄録

Ethyl 2-methoxymethylene-3-ethoxypropionate (III) undergoes condensation with urea, and N-substituted urea in ethanol solution in the presence of hydrochloric acid. With urea, III gave ethyl 2-oxo-1, 2, 3, 4-tetrahydro-5-pyrimidinecarboxylate (V), with N-methyl-urea a mixture of ethyl 2-oxo-methyl-1, 2, 3, 4-tetrahydro-5-pyrimidinecarboxylate (XIII) and its isomeric 1-methyl compound (XIV), which was separated into each isomer, and with N-phenylurea the 1-phenyl compound (XV) was exclusively obtained. Conversion into pyrimidines was achieved by dehyrogenation and subsequent chlorination of V.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 12 (7), 804-808, 1964

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204171876224
• NII論文ID: 110003619386
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.12.804
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 14206932
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/12/7/12_7_804/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1965054809
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可