Use of van der Waals volume in structure-activity studies.

• 森口 郁生

• 叶田 やよい

抄録

Several structure-activity data which had been analysed using molar attraction constant, partition coefficient, connectivity index, and molar refraction as a parameter for drug structure were reexamined by the use of van der Waals volume (V_W). These data included actibacterial activity of penicillins, tadpole narcosis with miscellaneous compounds, inhibition of neuraminidase by dihydroisoquinolines, fungus toxicity with miscellaneous molecules, inhibition of xanthine oxidase by phenylguanines, and tuberculostatic activity of isoniazid derivatives. In all the cases, very significant correlations were found by regression analysis. These findings supported the generality of the use of V_W to analyse and predict biological activity relating to molecular structure.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 25 (5), 926-935, 1977

  公益社団法人 日本薬学会

キーワード

• tuberculostatic activity

詳細情報

• CRID: 1390001204169378816
• NII論文ID: 110003622506
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.25.926
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 264185
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/25/5/25_5_926/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1978031346
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可