Controlled drug permeation. II. Comparative permeability and stability of butamben and benzocaine.
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抄録
Local anesthetic agents, benzocaine and butamben were compared for their permeabilities to silicone membrane and stabilities against hydrolytic degradations in 0.05N NaOH solutions. Butamben permeated through the membrane from the suspension to the same extent as benzocaine in spite of smaller solubility in water. Calculated stability of butamben in suspension was about 10 times greater than benzocaine due to smaller hydrolytic rate constant and smaller solubility. These properties of butamben may be favorable for the delivery system using a silicone membrane as a release-controlling barrier.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 25 (5), 1098-1100, 1977
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679146093824
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- NII論文ID
- 110003622531
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- PubMed
- 264175
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可