An improved attachment of N-protected amino acid and peptide to chloromethylated polystyrene-divinylbenzene resin.

• 鈴木 謙次

• 遠藤 信義

抄録

N-Protected amino acyl-or peptidyl-resin was prepared in good yield without racemization, when about a half equivalent amount of 1, 5-diaza-bicyclo [4, 3, 0] nonene-5 (DBN) or 1, 8-diaza-bicyclo [5, 4, 0] undecene-7 (DBU) salt of N-protected amino acid or peptide was allowed to react with chloromethylated polystyrene-2%-divinylbenzene resin (chlorine content 0.66 millimole per gram) at 50°for 28 hours. The unchanged chloromethyl group was acetylated quantitatively by the reaction with large excess of DBN salt of acetic acid.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 25 (5), 1143-1146, 1977

  公益社団法人 日本薬学会

キーワード

• racemization test

詳細情報

• CRID: 1390282679148150784
• NII論文ID: 110003622542
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.25.1143
• COI: 1:CAS:528:DyaE2sXltValtrw%3D
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/25/5/25_5_1143/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1978031536
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可