Effect of Isoxazolyl-penicillin on the Rectal Absorption of Ampicillin in Rabbits and Humans

• 村上 照夫

• 矢田 登

  Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine

• 鎌田 皎

  Faculty of Pharmaceutical Sciences, Osaka University

抄録

The effects of isoxazolyl-penicillins on the rectal absorption of ampicillin were investigated in rabbits and humans. The bioavailability of ampicillin following administration of a suppository in the presence or absence of an isoxazolyl-penicillin was determined from the blood level in rabbits and from the urinary excretion (0-6 h) in humans. Rectal absorption of ampicillin from the suppository was enhanced by the presence of an isoxazolyl-penicillin in both rabbits and humans, though the effect was much greater in rabbits than in humans. The absorption-promoting effects of isoxazolyl-penicillins appeared to be related to their partition coefficients between n-octanol and buffer solution (pH 7.4).

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 31 (5), 1708-1713, 1983-05-25

  公益社団法人日本薬学会

キーワード

• rectal absorption
• isoxazolyl-penicillin
• penicillin
• bioavailability of ampicillin
• promoting effect of isoxazolyl-penicillins for rectal absorption of ampicillin

詳細情報

• CRID: 1571135652460891008
• NII論文ID: 110003624327
• NII書誌ID: AA00602100
• ISSN: 00092363
• Web Site: https://search.jamas.or.jp/link/ui/1984149559
• 本文言語コード: en
• データソース種別:
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