Studies on Quinoline and Isoquinoline Derivatives. IX. Synthesis of Pyrrolo [1,2-b] isoquinolines from 3-Bromoisoquinoline Derivatives
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The reaction of 3-bromo-1-methoxyisoquinoline with propargyl alcohol in the presence of dichlorobis (triphenylphosphine) palladium and cuprous iodide gave 3-(1-methoxy-3-isoquinolyl) propargyl alcohol in good yield. Cyclization of 3-(1-methoxy-3-isoquinolyl) propanol obtained by the catalytic reduction of the propargyl alcohol, afforded a 1,2,3,5-tetrahydropyrrolo [1,2-b] isoquinoline derivative. The synthesis of a pyrrolo [3,2,1-de] phenanthridine derivative was accomplished by the introduction of an acrylic acid moiety into the pyrrolo [1,2-b] isoquinoline and subsequent reduction and cyclization of the resulting ethyl pyrrolo [1,2-b] isoquinoline-10-acrylate.
収録刊行物
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- Chemical & pharmaceutical bulletin
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Chemical & pharmaceutical bulletin 31 (7), 2275-2280, 1983-07-25
公益社団法人日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1570291227531885696
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- NII論文ID
- 110003624418
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- NII書誌ID
- AA00602100
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- ISSN
- 00092363
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles