Isolation and Antitumor Activity of Cyclic Hexapeptides Isolated from Rubiae Radix

• 糸川 秀治

• 竹谷 孝一

  Tokyo College of Pharmacy

• 森 登

  Tokyo College of Pharmacy

• 浜中 敏議

  Tokyo College of Pharmacy

• 薗部 徹

  Tokyo College of Pharmacy

• 三原 和彦

  Tokyo College of Pharmacy

抄録

The details of the isolation and antitumor activity of cyclic hexapeptides (RA-VII, RA-V, RA-IV and RA-III) isolated from Rubia cordifolia are reported. Studies on a spectrum of experimental tumors in mice revealed that the peptides exhibited significant activity against leukemias and ascites tumors, P-388,L1210,B-16 melanoma and solid tumors, colon 38,Lewis lung carcinoma and Ehrlich carcinoma. RA-V had an especially potent effect on MM2 mammary carcinoma in mice. The effective dose range of RA-IV against P-388 leukemia was different from those of the other cyclic hexapeptides.

収録刊行物

• Chem. Pharm. Bull.

  Chem. Pharm. Bull. 32 284-290, 1984

  公益社団法人日本薬学会

キーワード

• Rubia cordifolia
• isolation of antitumor substance
• antitumor activity
• murine tumor
• cyclic hexapeptide

詳細情報

• CRID: 1573668927251511936
• NII論文ID: 110003624616
• NII書誌ID: AA00602100
• ISSN: 00092363
• Web Site: https://search.jamas.or.jp/link/ui/1985108998
• 本文言語コード: en
• データソース種別:
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