Synthesis of Diclofenac

• 田村 恭光

  Faculty of Pharmaceutical Sciences, Osaka University

• 上西 潤一

  Faculty of Pharmaceutical Sciences, Osaka University

• CHOI HONGDAE

  Faculty of Pharmaceutical Sciences, Osaka University

• 春田 純一

  Faculty of Pharmaceutical Sciences, Osaka University

• 石橋 弘行

  Faculty of Pharmaceutical Sciences, Osaka University

抄録

Diclofenac, a potent antiinflammatory agent, was prepared by acid-catalyzed cyclization of N-(2,6-dichlorophenyl)-α-(methylsulfinyl) acetanilide or of α-chloro-N-(2,6-dichlorophenyl)-α-(methylthio) acetanilide followed by desulfurization and hydrolysis of the resultant 1-(2,6-dichlorophenyl)-3-(methylthio) oxindole.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 32 (5), 1995-1997, 1984-05-25

  公益社団法人日本薬学会

キーワード

• acid-catalyzed cyclization of α-(methylsulfinyl) acetanilide
• antiinflammatory agent
• diclofenac
• Friedel-Crafts cyclization of α-chloro-α-(methylthio) acetanilide
• oxindole (indolin-2-one)

詳細情報

• CRID: 1572261552368666240
• NII論文ID: 110003625006
• NII書誌ID: AA00602100
• ISSN: 00092363
• Web Site: https://search.jamas.or.jp/link/ui/1985075790
• 本文言語コード: en
• データソース種別:
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