Mutagenic Activity, Antibacterial Activity and Enzymatic Reducibility of Geometrical Isomers of Nitrofurans in Salmonella typhimurium TA100

  • 加藤 安彦
    Department of Environmental Sciences, Kyushu Institute of Technology
  • 尾川 博昭
    The Kitakyushu Municipal Institute for Environmental Health Sciences
  • 只隈 邦彦
    Department of Environmental Sciences, Kyushu Institute of Technology
  • 柿本 幸司
    Department of Environmental Sciences, Kyushu Institute of Technology
  • 鶴田 暁
    Kitakyushu Kogai-gijutsu Center
  • 北村 繁幸
    Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
  • 辰己 淳
    Institute of pharmaceutical Sciences, Hiroshima University School of Medicine

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Mutagenic activity, antibacterial activity and enzymatic reducibility of geometrical isomers of several nitrofurans were examined comparatively in Salmonella typhimurium TA100. These biological activities were well correlated to each other, not only between cis and trans isomers of each nitrofuran, but also among all the nitrofurans tested. Furthermore, the reducibility of each pair of cis and trans isomers by the bacterial enzymes also appeared to be correlated to the above biological activities.

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