Oxidation of 1,3-dimethyl derivatives of pyrimidine bases with m-chloroperbenzoic acid.

• Harayama Takashi

• Kotoji Kayoko

• Yoneda Fumio

• Taga Tooru

• Osaki Kenji

• Nagamatsu Tomohisa

Abstract

Oxidation of 1, 3-dimethylthymine (1), 1, 3-dimethyluracil (2), and 5-fluoro-1, 3-dimethyluracil (3) with m-chloroperbenzoic acid were investigated. 1 gave the cis diol 5, 6-dihydrothymine derivative (4) stereoselectively. Its stereostructure was definitely determined by an X-ray analysis. 2 afforded 7, 8, and 9, and 3 afforded 8.

Journal

• Chemical and Pharmaceutical Bulletin

  Chemical and Pharmaceutical Bulletin 32 (5), 2056-2058, 1984

  The Pharmaceutical Society of Japan

Keywords

• cis 5, 6-dihydroxy-5, 6-dihydroxy-5, 6-dihydrothymine

Details

• CRID: 1390001204167088128
• NII Article ID: 110003625021
• NII Book ID: AA00602100
• DOI: 10.1248/cpb.32.2056
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/32/5/32_5_2056/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1985075840
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed