Structure Confirmation of Active Metabolite of Dicloxacillin in Man by Nuclear Magnetic Resonance Spectroscopy

• 村井 靖夫

  Faculty of Pharmaceutical Sciences, Kyoto University

• 中川 照眞

  Faculty of Pharmaceutical Sciences, Kyoto University

• 奥村 一夫

  Faculty of Pharmaceutical Sciences, Kyoto University

• 宇野 豊三

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

抄録

The active metabolite of dicloxacillin was isolated from human urine, and its structure was investigated. The ^1H-nuclear magnetic resonance (NMR) and ^<13>C-NMR spectra indicated that one proton had been lost from the 5-methyl group of dicloxacillin. Fast atom bombardment mass spectra showed that one oxygen atom had been added to dicloxacillin by the biotransformation. These results confirmed that hydroxylation of the methyl group at the 5-position of the isoxazolyl moiety of dicloxacillin occurs to yield the active metabolite.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 32 (8), 3277-3280, 1984-08-25

  公益社団法人日本薬学会

キーワード

• dicloxacillin
• active metabolite
• metabolism
• urinary excretion
• ^1H-NMR
• ^<13>C-NMR
• fast atom bombardment mass spectroscopy
• isoxazolylpenicillin

詳細情報

• CRID: 1571135652461822336
• NII論文ID: 110003625082
• NII書誌ID: AA00602100
• ISSN: 00092363
• Web Site: https://search.jamas.or.jp/link/ui/1985109110
• 本文言語コード: en
• データソース種別:
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