Novel biotransformation of a 2-pyrone to a substituted benzoic acid

  • 桜井 郁男
    Faculty of Pharmaceutical Sciences, Kanazawa University
  • 鈴木 晴美
    Faculty of Pharmaceutical Sciences, Kanazawa University
  • 清水 栄
    Faculty of Pharmaceutical Sciences, Kanazawa University
  • 山本 譲
    Faculty of Pharmaceutical Sciences, Kanazawa University

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It was found that Macrophoma commelinae (IFO 9570) had an ability to transform 5-acetyl-4-methoxy-6-methyl-2-pyrone (1) to 4-acetyl-3-methoxy-5-methylbenzoic acid (2). This biotransformation was investigated using 13C- and 14C-labeled compounds. It is likely that 2 is formed by condensation of the added 2-pyrone and a catabolic pyruvate.

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