Changes in Physical Characteristics of Ethylaminobenzoate Tablets during Storage

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The changes in the physical characteristics of the tablets containing ethylaminobenzoate during storage under drying conditions at different temperatures below the melting point were investigated. Changes in the crushing strength of the tablets, the disintegration properties of the tablets, the penetrating speed of water into the tablets and the pore diameter in the tablets were apparent even below the melting point. These changes tended to become larger at higher storage temperature. Based on a comparison with the results for stored tablets composed of only one component, it is considered that one of the causes of these changes is sintering. It is suggested that these changes are affected by the excipients in the tablets.

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