Studies on β-Lactam Antibiotics. XIV. : Synthesis and Biological Activity of the (E)-Isomer of FK027

• KAWABATA KOHJI

  Central Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,

• 宮井 健二

  Central Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,

• 高杉 寿

  Central Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,

• 高谷 隆男

  Central Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,

抄録

The (E)-isomer (11) of FK027 was synthesized by two methods. The effect of the configuration of the oxime in the 7-acyl side chain of FK027 (1) on the antimicrobial activity and oral absorbability in rats was investigated. Both FK027 (1) and its (E)-isomer (11) showed appreciable oral absorbability regardless of the configuration of the oxime.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 34 (8), 3458-3464, 1986-08-25

  公益社団法人日本薬学会

キーワード

• (E)-isomer
• isomerization
• (E)-2-alkoxyimino-4-chloro-3-oxobutyric acid
• oral absorption
• X-ray analysis
• oral cephalosporin
• FK027
• antimicrobial activity

詳細情報

• CRID: 1571417127437495680
• NII論文ID: 110003626563
• NII書誌ID: AA00602100
• ISSN: 00092363
• Web Site: https://search.jamas.or.jp/link/ui/1987079012
• 本文言語コード: en
• データソース種別:
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