Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Lignan Glucosides of Eucommia Bark

• 出山 武

  Central Reseach Laboratories, Yomeishu Seizo Co., Ltd.,

• 西部 三省

  Faculty of Pharmaceutical Sciences, Higashi Nippon Gakuen University

• 北川 静香

  Faculty of Pharmaceutical Sciences, Higashi Nippon Gakuen University

• 荻原 幸夫

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 竹田 忠紘

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 大本 太一

  School of Pharmaceutical Sciences, Toho University

• 二階堂 保

  School of Pharmaceutical Sciences, Toho University

• 三川 潮

  Faculty of Pharmaceutical Sciences, University of Tokyo

抄録

Studies were conducted on adenosine 3', 5'-cyclic monophosphate (cyclic AMP) phosphodiesterase inhibition by lignan glucosides from bark of Eucommia ulmoides OLIV. (Eucommiaceae). Various lignan diglucosides. (+)-syringaresinol di-O-β-D-glucopyranoside (1c), (+)-medioresinol di-O-β-D-glucopyranoside (2c), (+)-pinoresinol di-O-β-D-glucopyranoside (3c) and (+)-1-hydroxy-pinoresinol 4', 4"-di-O-β-D-glucopyranoside (4d), showed strong inhibitory activity.The structure-inhibitory activity relationships of the aglycone and its glucosides are discussed. The order of inhibitory effect was diglucoside ≩︀ aglycone > monoglucoside.

収録刊行物

• Chem. Pharm. Bull.

  Chem. Pharm. Bull. 36 435-439, 1988

  公益社団法人日本薬学会

キーワード

• cyclic AMP phosphodiesterase
• inhibitor
• Eucommia ulmoides
• lignan glucoside
• (+)-syringaresinol di-O-β-D-glucopyranoside
• (+)-medioresinol di-O-β-D-glucopyranoside
• (+)-pinoresinol di-O-β-D-glucopyranoside
• (+)-1-hydroxypinoresinol 4', 4"-di-O-β-D-glucopyranoside
• structure-inhibitory activity relationship

詳細情報

• CRID: 1570009752553542144
• NII論文ID: 110003626710
• NII書誌ID: AA00602100
• ISSN: 00092363
• 本文言語コード: en
• データソース種別:
  • CiNii Articles