Studies on Peptides. CLXIII. : Synthesis of Guinea Pig Vasoactive Intestinal Polypeptide(gVIP)

• 波多野 美香

  Faculty of Pharmaceutical Sciences

• 船越 奨

  Faculty of Pharmaceutical Sciences

• 藤井 信孝

  Faculty of Pharmaceutical Sciences

• 武山 正治

  Chest Disease Research Institute

• 尹 光俊

  the 1st Surgery Department, Faculty of Medicine, Kyoto University

• 井上 一知

  the 1st Surgery Department, Faculty of Medicine, Kyoto University

• 小切 匡史

  the 1st Surgery Department, Faculty of Medicine, Kyoto University

• 戸部 隆吉

  the 1st Surgery Department, Faculty of Medicine, Kyoto University

• 矢島 治明

  Faculty of Pharmaceutical Sciences

抄録

A 28-residue peptide corresponding to the entire amino acid sequence of vasoactive intestinal polypeptide of guinea pig origin (gVIP) was synthesized by assembling 6 peptide fragments, followed by thioanisole-mediated deprotection with 1 M trimethylsilyl trifluoromethanesulfonate in tiffluoroacetic acid. The synthetic peptide was biologically as active as synthetic porcine VIP, but behaved immunologically in a different manner from the above mammalian VIP.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 36 (10), 3857-3866, 1988-10-25

  公益社団法人日本薬学会

キーワード

• guinea pig vasoactive intestinal polypeptide
• VIP synthesis
• β-cycloheptyl-aspartate
• Asp-succinimide formation
• hard acid deprotection
• trimethylsilyl trifluoromethanesulfonate
• pancreatic blood flow
• immunological properties

詳細情報

• CRID: 1570291227530265728
• NII論文ID: 110003626732
• NII書誌ID: AA00602100
• ISSN: 00092363
• Web Site: https://search.jamas.or.jp/link/ui/1989195446
• 本文言語コード: en
• データソース種別:
  • CiNii Articles