Studies on Peptides. CLXV. : Combination of a New Amide-Precursor Reagent and Trimethylsilyl Bromide Deprotection for the 9-Fluorenylmenthyloxycarbonyl-Based Solid-Phase Synthesis of chicken Antral Peptide

• 郭 莉莉

  Faculty of Pharmaceutical Sciences, Kyoto University

• 船越 奨

  Faculty of Pharmaceutical Sciences, Kyoto University

• 藤井 信孝

  Faculty of Pharmaceutical Sciences, Kyoto University

• 矢島 治明

  Faculty of Pharmaceutical Sciences, Kyoto University

抄録

A 36-residue peptide amide corresponding to the entire amino acid sequence of chicken antral peptide was synthesized by the 9-fluorenylmethyloxycarbonyl (Fmoc)-based solid-phase synthesis, for which a new amide precursor reagent, 3-(α-Fmoc-amino-4-methoxybenzyl)-4-methoxyphenyl-propionic acid, was employed in combination with thioanisole-mediated trimethylsilyl bromide deprotection. A homogeneous standard sample prepared by the solution-phase method was used to check the effectiveness of the purification step.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 36 (12), 4989-4992, 1988-12-25

  公益社団法人日本薬学会

キーワード

• new amide precursor reagent
• modified benzhydroylamine resin
• hard acid deprotection
• thioanisole-mediated deprotection
• trimethylsilyl bromide deprotection
• Fmoc-based solid phase synthesis
• amide peptide synthesis

詳細情報

• CRID: 1574231877205516288
• NII論文ID: 110003626840
• NII書誌ID: AA00602100
• ISSN: 00092363
• 本文言語コード: en
• データソース種別:
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