Cross-Coupling of N-Heteroaryl Halides with Active Methylene Compounds in the Presence of Tetrakis(triphenylphosphine)palladium

• 坂本 尚夫

  Pharmaceutical Institute, Tohoku University

• 加藤 栄作

  Pharmaceutical Institute, Tohoku University

• 根東 義則

  Pharmaceutical Institute, Tohoku University

• 山中 宏

  Pharmaceutical Institute, Tohoku University

抄録

The cross-coupling of 3-iodo- and 3-bromopyridine with the carbanions derived from ethyl cyanoacetate and malononitrile in the presence of tetrakis(triphenylphosphine)palladium in 1,2-dimethoxyethane gave ethyl α-cyanopyridine-3-acetate and 3-pyridinemalononitrile in moderate yields. This palladium-catalyzed cross-coupling proceeded smoothly with halopyrimidines, haloquinolines, haloisoquinolines, and also bromobenzene.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 36 (5), 1664-1668, 1988-05-25

  公益社団法人日本薬学会

キーワード

• tetrakis(triphenylphosphine)palladium
• aryl halide
• N-heteroaryl halide
• ethyl cyanoacetate
• malononitrile
• ethyl α-cyanoareneacetate
• arenemalononitrile

詳細情報

• CRID: 1573950402229494912
• NII論文ID: 110003626974
• NII書誌ID: AA00602100
• ISSN: 00092363
• 本文言語コード: en
• データソース種別:
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