Synthesis of [^<13>C]Phenacetin and Its Application ot the Breath Test for the Diagnosis of Liver Disease

• 車谷 勝行

  Department of Medicinal Chemistry, Meiji College of Pharmacy

• 梶原 正宏

  Department of Medicinal Chemistry, Meiji College of Pharmacy

• 安部井 徹

  Second Department of Internal Medicine, School of Medicine, Toho University

• 平野 修助

  Second Department of Physiology, School of Medicine, Toho University

• 国分 信彦

  Japan Spectroscopic Co., Ltd.,

抄録

N-(4-([1-^<13>C]Ethoxy)phenyl)acetamide (^<13>C-phenacetin) was prepared by two methods. In the first method, p-nitrophenol was alkylated with [1-^<13>C]iodoethane and reduced to give 4-([1-^<13>C]ethoxy)aniline (^<13>C-p-phenetidine), which was acetylated with acetic anhydride to give ^<13>C-phenacetin. In the second method, N-acetyl-p-aminophenol was alkylated with [1-^<13>C]iodoethane. By using an excess amount of the starting material, [1-^<13>C]iodoethane was convrted to ^<13>C-phenacetin in high yield. The ^<13>C-phenacetin thus obtained was applied to the breath test, and could be detected by ^<13>CO_2 analyzer. Thus, the ^<13>C-phenacetin breath test should be applicable to the diagnosis of liver disease.

収録刊行物

• Chem. Pharm. Bull.

  Chem. Pharm. Bull. 36 2679-2681, 1988

  公益社団法人日本薬学会

キーワード

• ^<13>C-phenacetin
• ^<13>C-p-nitrophenetole
• [1-^<13>C]iodoethane
• ^<13>C-p-phenetidine
• breath test
• ^<13>CO_2 analyzer
• liver disease

詳細情報

• CRID: 1573387452276042624
• NII論文ID: 110003627127
• NII書誌ID: AA00602100
• ISSN: 00092363
• Web Site: https://search.jamas.or.jp/link/ui/1990050765
• 本文言語コード: en
• データソース種別:
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