Condensed Heteroaromatic Ring Systems. XVI. : Synthesis of Pyrrolo[2,3-d]pyrimidine Derivatives

• 根東 義則

  Pharmaceutical Institute, Tohoku University

• 渡邊 亮

  Pharmaceutical Institute, Tohoku University

• 坂本 尚夫

  Pharmaceutical Institute, Tohoku University

• 山中 宏

  Pharmaceutical Institute, Tohoku University

抄録

The synthesis of pyrrolo[2,3-d]pyrimidine derivatives was accomplished by the following two methods. One is the palladium-catalyzed reaction terminal acetylenes with N-(5-halo-4-pyrimidinyl)methanesulfonamides prepared by the nucleophilic substitution of 4-chloro-5-halopyrimidines with methanesulfonamide. The other is the photocyclization of 4-azidopyrimidines containing an olefinic function at the 5-position. The synthesis of 4-azidopyrimidine derivatives is also described.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 37 (11), 2933-2936, 1989-11-25

  公益社団法人日本薬学会

キーワード

• pyrrolo[2, 3-d]pyrimidine
• palladium-catalyzed reaction
• N-(5-halo-4-pyrimidinyl)methanesulfonamide
• acetylene
• photochemical cyclization
• 4-azidopyrimidine
• nucleophilic substitution
• 4-chloropyrimidine
• methanesulfonamide

詳細情報

• CRID: 1573387452275854080
• NII論文ID: 110003627366
• NII書誌ID: AA00602100
• ISSN: 00092363
• 本文言語コード: en
• データソース種別:
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