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Abstract
Oxygenated lanosterol derivatives, which were isolated from Ganoderma lucidum (Polyporaceae) or their derivatives obtained by chemical conversion, were tested for their effect on cholesterol biosynthesis from 24,25-dihydrolanosterol by rat hepatic subscellular 10,000 x g supernatant fraction. The sterol (VI, 40 μM) with 7-oxo and 15α-hydroxy groups potently inhibited the synthesis of cholesterol from [24,25-^3H]-24,25-dihydrolanosterol (18 μM).
Journal
- Chemical & pharmaceutical bulletin [List of Volumes]
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Chemical & pharmaceutical bulletin 37(2), 531-533, 1989-02-25 [Table of Contents]
The Pharmaceutical Society of Japan
