Molecular State of Methyl p-Hydroxybenzoate in the Solid Dispersion Prepared by Grinding with α-Cyclodextrin

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Abstract

The molecular interaction in a ground mixture of α-cyclodextrin (α-CD) and methyl p-hydroxybenzoate (MPHB) has been studied as a function of the mixing molar ratio. The states of MPHB molecules were investigated by means by powder X-ray diffraction, differential scanning calorimetry measurement and the determination of remaining MPHB after sublimation. The results indicated that in the ground mixture the MPHB molecules could exist in a mono-molecular dispersed state in the hydrogen bonding network of α-CD as well as in the α-CD cavity. It was suggested that two types of crystalline MPHB, fine crystals embedded in the α-CD matrix and intact crystals, were also present in the ground mixture of molar ratio 5 (MPHB/α-CD) or above.

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Details 詳細情報について

  • CRID
    1570572702508068224
  • NII Article ID
    110003627882
  • NII Book ID
    AA00602100
  • ISSN
    00092363
  • Text Lang
    en
  • Data Source
    • CiNii Articles

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