FORMULATION-ASSISTED BIODEGRADABLE POLYMER MATRICES

Search this article

Abstract

A method is proposed to control degradation rates of biodegradable polyester matrices for DDS and medical implantable materials. The degradation rates of poly(lactic acid), poly β-hydroxybutyrate and β-hydroxybutyrate-valerate copolymer matrices, which have poor degradability, could be accelerated by incorporating basic compounds, such as cinnarizine and clonidine, as a hydrolysis accelerator. The rates could be controlled by changing the loading amount and the basicity of the basic compounds.

Journal

Keywords

Details 詳細情報について

  • CRID
    1572261552368452864
  • NII Article ID
    110003627903
  • NII Book ID
    AA00602100
  • ISSN
    00092363
  • Text Lang
    en
  • Data Source
    • CiNii Articles

Report a problem

Back to top