Prosessing of Nux Vomica. II. : Changes in Alkaloid Composition of the Seeds of Strychnos nux-vomica on Traditional Drug-Processing

• 蔡 宝晶

  Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University

• 服部 征雄

  Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University

• 難波 恒雄

  Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University

抄録

In the course of our study on the drug-processing of the seeds of Strychnos nux-vomica L. (Loganiaceae), the alkaloid composition of the heat-treated seeds of S. nux-vomica was compared to that of the untreated seeds. On heat treatment, the contents of the major alkaloids such as strychnine and brucine declined significantly with increases in the amounts of isostrychnine, isobrucine, strychnine N-oxide and brucine N-oxide. The cleavage of an ether linkage and the occurrence of N-oxidation were demonstrated by heat treatment of authentic strychnine and brucine.

収録刊行物

• Chem. Pharm. Bull.

  Chem. Pharm. Bull. 38 1295-1298, 1990

  公益社団法人日本薬学会

キーワード

• brucine
• drug-processing
• isobrucine
• isostrychnine
• Loganiaceae
• strychnine
• Strychnos nux-vomica
• strychnos alkaloids

詳細情報

• CRID: 1571417127437916928
• NII論文ID: 110003628535
• NII書誌ID: AA00602100
• ISSN: 00092363
• 本文言語コード: en
• データソース種別:
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