Marine Sterols. XIX. Polyhydroxysterols of the Soft Corals of the Andaman and Nicobar Coasts. (3). Isolation and Structures of Five New C_<28> Polyhydroxysterols from Two Sclerophytum sp. Soft Corals

• KOBAYASHI Masaru

  Faculty of Pharmaceutical Sciences, Hokkaido University

• KANDA Fuyuko

  Faculty of Pharmaceutical Sciences, Hokkaido University

• RAO Chunduri Venkata Lakshmana

  School of Chemistry, Andhra University

• KUMAR Saridi Madhava Dileep

  School of Chemistry, Andhra University

• RAO Desaraju Venkata

  Department of Pharmaceutical Sciences, Andhra University

• RAO Chaganti Bheemasankara

  School of Chemistry, Andhra University

Abstract

Nine polyhydroxysterols were isolated from the lipid extract of two Sclerophytum sp. soft corals collected in the Andaman and Nicobar Islands. Of these, three compounds (7a, b, and 8) had previously been isolated from the southern Japan soft coral Sarcophyton glaucum. Compound 1 was identified as lobosterol having a novel 6-keto-A/B-cis ring juncture. The structures of the five new compounds were determined as 25-deacetyllobosterol (2), (24S)-24-methylcholest-7-ene-3β, 5α, 6β, 25-tetrol 25-monoacetate (3), (24S)-24-methylcholest-22E-ene-3β, 5α, 6β, 25-tetrol (4), (24S)-24-methylcholestane-3β, 5α, 25-triol-6-one 25-monoacetate (5a) and its C-25 deacetoxy analog (6), from the spectral data and by chemical conversion.

Journal

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 39 (2), 297-300, 1991-02-25

  The Pharmaceutical Society of Japan

Keywords

• coelenterata
• soft coral
• Sclerophytum sp.
• polyhydroxy C_<28> sterol
• 25-deacetyllobosterol
• 24-methylcholest-7-ene-3β, 5α, 6β, 25-tetrol 25-monoacetate
• 24-methylcholest-22E-ene-3β, 5α, 6β, 25-tetrol
• 24-methylcholestane-3β, 5α, 25-triol-6-one 25-monoacetate
• 24-methylcholestane-3β, 5α-diol-6-one

Details

• CRID: 1572261552367182080
• NII Article ID: 110003629107
• NII Book ID: AA00602100
• ISSN: 00092363
• Text Lang: en
• Data Source:
  • CiNii Articles