Factors Effecting Spherical Granulation of Drugs by Tumbling Granulation Method
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Factors effecting spherical beads granulation by using centrifugal fluidizing granulator were studied. Spherical beads were prepared by feeding powdered drugs on Non-pareil-103 while spraying a binder solution containing various sugars or polymers.Effect of binder species on the granulation was compared using nicotinamide as a model drug. Aqueous solutions of polyemrs commonly gave beads of high crushing strength, however, serious agglomeration of beads was observed. Aqueous sucrose solution produced beads of the highest strength with less agglomeration, while other sugars produced fairly fragile beads.Various drugs with different solubilities were granulated using aqueous sucrose solution as a binder to examine the effect of physicochemical properties of drugs on the granulatability. Water-soluble drugs such as nicotinamide or isoniazid produced spherical beads with a smooth surface, whereas slightly water-soluble drugs such as tipepidine hibenzate or bisbentiamine produced beads of irregular shape and rough surfaces. Dusting of powders was little in the former but was serious in the latter.The granulatability of these slightly water-soluble drugs was greatly improved by adding ethanol in the binder solution and the optimal ethanol concentration was around 30%. At this concentration, immersional wetting (Γ・cosθ) of the solvent to these drugs took the maximum value. On the basis of these findings, the granulatability of drugs using a CF granulator was discussed in relation to the solubility and wettability of drugs to the binder solvent.
収録刊行物
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- Chem.Pharm.Bull.
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Chem.Pharm.Bull. 40 488-492, 1992
公益社団法人日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1571417127438472704
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- NII論文ID
- 110003629793
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- NII書誌ID
- AA00602100
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- ISSN
- 00092363
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles