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Abstract
Novel indolo[3,2-b]quinoline derivatives (1c-f), which carried a methoxy or a hydroxy group at the 4- or 7-position of the lead compound 1a, were prepared and their antitumor activities against P388 in mice were examined. Except for the 4-hydroxy derivative (1d), these showed remarkably potent activity. Among these compounds, the 7-hydroxy derivative (1f) was the most potent one (optimal dose=50mg/kg, the median survival time of treated group/control group (T/C)>330%, cure=5/6).
Journal
- Chemical & pharmaceutical bulletin [List of Volumes]
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Chemical & pharmaceutical bulletin 40(2), 528-530, 1992-02-25 [Table of Contents]
The Pharmaceutical Society of Japan
