Inhibitory effects of some natural products on the activation of hyaluronidase and their anti-allergic actions

  • 掛川 寿夫
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University
  • 松本 仁
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University
  • 佐藤 利夫
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University

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抄録

The anti-allergic drugs disodium cromoglycate (DSCG) and tranilast are strong inhibitors of hyaluronidase. In the development of new anti-allergic drugs, we studied the inhibitory effects of some natural products on the activation of hyaluronidase. Among the compounds tested, liquiritigenin, isoliquiritigenin and baicalein showed dose-related inhibitory effects. Anti-allergic activities of these compounds were evident from the facts that they inhibited the histamine release from rat peritoneal exudate cells induced by antigen, compound 48/80 and calcium ionophore A-23187,and from their inhibitory effect on Shultz-Dale reaction using sensitized guinea pig ileum.

収録刊行物

  • Chem. Pharm. Bull.

    Chem. Pharm. Bull. 40 1439-1442, 1992

    公益社団法人日本薬学会

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