Inhibitory effects of some natural products on the activation of hyaluronidase and their anti-allergic actions
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The anti-allergic drugs disodium cromoglycate (DSCG) and tranilast are strong inhibitors of hyaluronidase. In the development of new anti-allergic drugs, we studied the inhibitory effects of some natural products on the activation of hyaluronidase. Among the compounds tested, liquiritigenin, isoliquiritigenin and baicalein showed dose-related inhibitory effects. Anti-allergic activities of these compounds were evident from the facts that they inhibited the histamine release from rat peritoneal exudate cells induced by antigen, compound 48/80 and calcium ionophore A-23187,and from their inhibitory effect on Shultz-Dale reaction using sensitized guinea pig ileum.
収録刊行物
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- Chem. Pharm. Bull.
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Chem. Pharm. Bull. 40 1439-1442, 1992
公益社団法人日本薬学会
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詳細情報
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- CRID
- 1572261552254868096
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- NII論文ID
- 110003630013
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- NII書誌ID
- AA00602100
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- ISSN
- 00092363
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles