Lipase-catalyzed resolution of racemic 1-acyloxy-2-(p-tolyl) propanes

被引用文献1件
  • 松本 高志
    Department of Applied Material Science, Faculty of Integrated Arts and Science University of Tokushima
  • 武田 美雄
    Department of Applied Material Science, Faculty of Integrated Arts and Science University of Tokushima
  • 寺尾 博充
    Department of Applied Material Science, Faculty of Integrated Arts and Science University of Tokushima
  • 高橋 智子
    Department of Applied Material Science, Faculty of Integrated Arts and Science University of Tokushima
  • 和田 眞
    Department of Chemistry, College of General Education University of Tokushima

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抄録

The acetate (11), propanoate (12), butanoate (13), 2-methylpropanoate (14), hexanoate (15), decanoate (16), and hexadecanoate (17) of (±)-2-(p-tolyl)-1-propanol (2) were predominantly hydrolyzed with lipase to give (S)-(-)-2-(p-tolyl)-1-propanol (2). However, the 2,2-dimethylpropanoate (18), benzoate (19), and phenylacetate (20) of (±)-2 were recovered intact even when the reaction was carried out for 100h. From the viewpoints of enentioselectivity and reaction rate, the racemic ester 11 was found to be the most suitable substrate for the optical resolution of (±)-2.

収録刊行物

  • Chem. Pharm. Bull.

    Chem. Pharm. Bull. 41 1459-1461, 1993

    公益社団法人日本薬学会

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詳細情報 詳細情報について

  • CRID
    1571980077279145088
  • NII論文ID
    110003630642
  • NII書誌ID
    AA00602100
  • ISSN
    00092363
  • 本文言語コード
    en
  • データソース種別
    • CiNii Articles

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