Cell Differentiation-Inducing Diterpenes from Andrographis paniculata NEES

• 松田 貴邦

  School of Pharmaceutical Sciences, University of Shizuoka

• 黒柳 正典

  School of Pharmaceutical Sciences, University of Shizuoka

• 杉山 聡子

  School of Pharmaceutical Sciences, University of Shizuoka

• 梅原 薫

  School of Pharmaceutical Sciences, University of Shizuoka

• 上野 明

  School of Pharmaceutical Sciences, University of Shizuoka

• 西 孝三郎

  Tsukuba Medicinal Plant Research Station, National Institute of Hygienic Sciences

抄録

The methanol extract of the aerial part of Andrographis paniculata NEES showed potent cell differentiation-inducing activity on mouse myeloid leukemia (M1) cells. From the ethyl acetate-soluble fraction of the methanol extract, six new diterpenoids of ent-labdane type, 14-epi-andrographolide (3), isoandrographolide (4), 14-deoxy-12-methoxyandrographolide (7), 12-epi-14-deoxy-12-methoxyandrographolide (8), 14-deoxy-12-hydroxyandrographolide (9) and 14-deoxy-11-hydroxyandrographolide (10) as well as two new diterpene glucosides, 14-deoxy-11,12-didehydroandrographi-side (12) and 6'-acetylneoandrographolide (14), and four new diterpene dimers, bis-andrograpolides A (15), B (16), C (17) and D (18), were isolated along with six known compounds. The structures of the diterpenoids were determined by means of spectral methods. Some of these compounds showed potent cell differentiation-inducing activity towards M1 cells.

収録刊行物

• Chem. Pharm. Bull.

  Chem. Pharm. Bull. 42 1216-1225, 1994

  公益社団法人日本薬学会

キーワード

• Andrographis paniculata
• Acanthaceae
• ent-labdane
• cell differentiation-inducing activity
• andrographolide
• diterpene dimer

詳細情報

• CRID: 1572543027231404544
• NII論文ID: 110003631115
• NII書誌ID: AA00602100
• ISSN: 00092363
• 本文言語コード: en
• データソース種別:
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