Mild and Facile Cleavage of 2-Cyanoethyl Ester Using Sodium Sulfide or Tetrabutylammonium Fluoride. Synthesis of 1,4-Dihydropyridine Monocarboxylic Acids and Unsymmetrical 1,4-Dihydropyridine Dicarboxylates

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抄録

Several 3-(2-cyanoethyl)-1,4-dihydropyridine carboxylates (16) were prepared in moderate to good yields by means of the Hantzsch reaction. Treatment of these carboxylates with a weak base such as sodium sulfide or tetrabutylammonium fluoride at room temperature afforded smoothly the corresponding 1,4-dihydropyridine monocarboxylic acids (18) in good yields. The monocarboxylic acids 18n and 18o were esterified with 2-nitrooxypropanol or N-(2-hydroxyethyl)nicotinamide p-toluenesulfonic acid salt to afford the selective coronary vasodilators CD-349 (5) and CD-832 (6), respectively.

収録刊行物

  • Chemical & pharmaceutical bulletin

    Chemical & pharmaceutical bulletin 42(8), 1579-1589, 1994-08-15

    公益社団法人日本薬学会

各種コード

  • NII論文ID(NAID)
    110003631192
  • NII書誌ID(NCID)
    AA00602100
  • 本文言語コード
    ENG
  • ISSN
    00092363
  • データ提供元
    NII-ELS 
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