Synthesis and Antipancreatitis Activities of Novel N-(2-Sulfonylamino-5-trifluoromethyl-3-pyridyl) carboxamide Derivatives as Phospholipase A_2 Inhibitors

• 木村 博彦

  Central Research Institute, Ishihara Sangyo Kaisha, Ltd.

• 四谷 収一

  Central Research Institute, Ishihara Sangyo Kaisha, Ltd.

• 湯木 俊次

  Central Research Institute, Ishihara Sangyo Kaisha, Ltd.

• 杉 秀男

  Central Research Institute, Ishihara Sangyo Kaisha, Ltd.

• 重原 格

  Technical Research Institute, Ishihara Sangyo Kaisha, Ltd.

• 芳賀 隆弘

  Corporate Strategy-Technology, Ishihara Sangyo Kaisha, Ltd.

抄録

Novel N-(2-sulfonylamino-5-trifluoromethyl-3-pyridyl)carboxamide derivatives have been prepared and evaluated as phospholipase A_2 (PLA_2) inhibitors. Among these compounds, IS-741 (sodium salt of 1j), which showed the highest and the most stable therapeutic effect on acute hemorrhagic pancreatitis induced by the closed duodenal loop method in rats, was selected as a candidate for further development.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 43 (10), 1696-1700, 1995-10-15

  公益社団法人日本薬学会

キーワード

• antipancreatitis agent
• phospholipase A_2 inhibitor
• N-pyridylsulfonamide
• IS-741

詳細情報

• CRID: 1570854177371422464
• NII論文ID: 110003631332
• NII書誌ID: AA00602100
• ISSN: 00092363
• 本文言語コード: en
• データソース種別:
  • CiNii Articles