Studies on Agents with Vasodilator and β-Blocking Activities, II

• 関 敏美

  Research Division, Teikoku Hormone Manufacturing Co., Ltd

• 竹崎 孝行

  Research Division, Teikoku Hormone Manufacturing Co., Ltd

• 大内 力男

  Research Division, Teikoku Hormone Manufacturing Co., Ltd

• 大藪 宏

  Research Division, Teikoku Hormone Manufacturing Co., Ltd

• 谷本 由隆

  Research Division, Teikoku Hormone Manufacturing Co., Ltd

• 山口 隆

  Research Division, Teikoku Hormone Manufacturing Co., Ltd

• 斎藤 守信

  Research Division, Teikoku Hormone Manufacturing Co., Ltd

• 石森 勉

  Research Division, Teikoku Hormone Manufacturing Co., Ltd

• 安田 喜久男

  Research Division, Teikoku Hormone Manufacturing Co., Ltd

抄録

A series of phenoxypropanolamines having a hydrazinopyridazinyl moiety was synthesized. Their hypotensive and β-blocking activities were evaluated after intravenous administration of the compounds to anethetized rats.Some of them exhibited both activities. In particular, compound 20k is a candidate for clinical use due to its hypotensive activity, equal to that of hydralazine, and its β-blocking activity, 2.7-fold more potent than that of propranolol.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 43 (2), 247-255, 1995-02-15

  公益社団法人日本薬学会

キーワード

• phenoxypropanolamine
• hydrazinopyridazine
• antihypertensive agent
• hypotensive activity
• β-blocking activity
• β_1-selectivity

詳細情報

• CRID: 1571980077278553216
• NII論文ID: 110003631451
• NII書誌ID: AA00602100
• ISSN: 00092363
• 本文言語コード: en
• データソース種別:
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