Stability of a 1β-Methylcarbapenem Antibiotic, Meropenem (SM-7388) in Aqueous Solution
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The stability and the degradation products of 1β-methylcarbapenem, meropenem in aqueous solution were investigated. In pH 4-8 dilute solution pseudo-first-order degradation was observed, and good stability of meropenem in aqueous solution was demonstrated by the effect of 1β-methyl group against hydrolysis of β-lactam ring. As degradation products, the β-lactam hydrolyzed product and the dimer product resulting from intermolecular aminolysis of β-lactam ring by the amine of the second molecule were described.
収録刊行物
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- Chemical & pharmaceutical bulletin
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Chemical & pharmaceutical bulletin 43 (4), 689-692, 1995-04-15
公益社団法人日本薬学会
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詳細情報
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- CRID
- 1570854177370790528
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- NII論文ID
- 110003631540
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- NII書誌ID
- AA00602100
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- ISSN
- 00092363
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles