Novel 2-Amino-1, 4-dihydropyridine Calcium Antagonists. I. Synthesis and Antihypertensive Effects of 2-Amino-1, 4-dihydropyridine Derivatives Having Nitroxyalkoxycarbonyl Groups at 3-and/or 5-Position

• 古林 隆司

  Pharmaceutical Research Department, Ube Laboratory, Corporate Research & Development, Ube Industries, Ltd.

• 井上 輝比古

  Pharmaceutical Research Department, Ube Laboratory, Corporate Research & Development, Ube Industries, Ltd.

• 北 純一郎

  Pharmaceutical Research Department, Ube Laboratory, Corporate Research & Development, Ube Industries, Ltd.

• 吉屋 晴夫

  Pharmaceutical Research Department, Ube Laboratory, Corporate Research & Development, Ube Industries, Ltd.

• 西野 繁栄

  Pharmaceutical Research Department, Ube Laboratory, Corporate Research & Development, Ube Industries, Ltd.

• 大泉 喜代志

  Sankyo Pharmacology and Molecular Biology Research Laboratories Sankyo Co., Ltd.

• 木村 富美夫

  Pharmaceutical Research Department, Ube Laboratory, Corporate Research & Development, Ube Industries, Ltd.

抄録

Novel 2-amino-1,4-dihydropyridine derivatives, which contain nitroxy-alkoxycarbonyl groups at the 3- and/or 5-position, were synthesized and their pharmaceutical effect was evaluated in spontaneously hypertensive rats. The structure-activity relationships are discussed in terms of potency, onset-rapidity, and duration of antihypertensive activity. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced on either side of an ester chain.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 43 (5), 788-796, 1995-05-15

  公益社団法人日本薬学会

キーワード

• 1, 4-dithydropyridine
• calciam antagonist
• antihypertensire effect
• spontaneously hypertensiverat
• structureactivity relationship

詳細情報

• CRID: 1572543027231055488
• NII論文ID: 110003631560
• NII書誌ID: AA00602100
• ISSN: 00092363
• 本文言語コード: en
• データソース種別:
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