Transformation and Excretion of Drugs in Biological Systems. IX. Interactions between Sulfinpyrazone and Sulfonamides, and between Oxyphenbutazone and Sulfonamides in Dogs

• 高田 昌彦

• 三沢 絢子

• 藤本 幸一

• 堀 了平

• 有田 隆一

抄録

Interactions between sulfinpyrazone and sulfonamides, and between oxyphenbutazone and sulfonamides, were investigated in dogs. The plasma level of sulfamethizole, sulfamethizole-N⁴-acetate and sulfisomezole-N⁴-acetate were prolonged by coadministration of sulfinpyrazone or oxyphenbutazone. But no alteration was observed in plasma level patterns of sulfisomezole and sulfanilamide. Sulfinpyrazone and oxyphenbutazone possess some displacing activity towards sulfonamides bound to dog plasma proteins. In renal clearance experiments, the clearance ratios of sulfamethizole, sulfamethizole-N⁴-acetate, and sulfisomezole-N⁴-acetate were markedly decreased after sulfinpyrazone infusion. The effect of oxyphenbutazone on sulfonamide excretion was relatively small compared with that of sulfinpyrazone, and oxyphenbutazone remarkably decreased the clearance ratio of sulfamethizole only. It became clear that prolongations of plasma levels of the certain sulfonamides by SPZ or OPB, are mainly caused by competitive interactions between the certain sulfonamides and the two anti-inflammatory drugs at renal secretory level.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 22 (3), 551-559, 1974

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679153391360
• NII論文ID: 110003633194
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.22.551
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 4424155
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/22/3/22_3_551/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1974081481
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可