Nuclear magnetic resonance studies of 2-amino- and 2-substituted amino-5,6-dihydroxy-1,2,3,4-tetrahydro-1-naphthalenols.

この論文をさがす

抄録

Carbon-13 and proton nuclear magnetic resonance studies were conducted on 2-aminoand 2-substituted amino-5, 6-dihydroxy-1, 2, 3, 4-tetrahydro-1-naphthalenols, which have a very potent β2-adrenoceptor-stimulating activity, especially in the trans isomer. The results suggested that in the trans isomer, the saturated part of the tetralin skeleton takes a half-chair conformation having both hydroxy and alkylamino groups in di-equatorial orientation. The structure coincides with the crystal structure of trans-2-cyclobutylamino-5, 6-dihydroxy-1, 2, 3, 4-tetrahydro-1-naphthalenol hydrobromide. The measurement of proton relaxation times of the trans-2-isopropyl derivative in solution indicated the existence of two equilibrium conformers related to the isopropylamino group, one having a conformation very similar to that of the cyclobutylamino analog in its solid state with respect to the C (2)-N+bond.

収録刊行物

キーワード

詳細情報

問題の指摘

ページトップへ