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The present investigation was undertaken to examine the exit mechanisms of D- and L-leucine compared with those of D- and L-alanine. The exit processes of D- and L-amino acids appear to consist mainly of an unsaturable process under physiological conditions. The exit velocities of D-leucine and D-alanine were slower than those of the corresponding L-amino acid under various conditions. A marked increase in the exit velocity of L-leucine was observed in the presence of gramicidin D. This is assumed to be due to the operation of an Na+-dependent carrier process. On the other hand, the exit of D-leucine was not accelerated, suggesting that the exit of D-leucine is little mediated by an Na+-dependent process, though the influx of D-leucine was well as that of L-leucine was partly mediated by an Na+-dependent process.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 29 (6), 1689-1693, 1981
公益社団法人 日本薬学会
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詳細情報
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- CRID
- 1390001204162678144
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- NII論文ID
- 110003633880
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- PubMed
- 7296718
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可