Mutagenicity of amide type and carbamate type diazoalkanegenerating agents in Salmonella/microsome assay.
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The mutagenicity of several N-nitroso compounds, RCONHCH2N(NO)R', which were reported as new diazoalkane-generating agents, was assayed by the Salmonella/microsome test. Among 6 amide type N-nitroso compounds which had an alkyl group at position R, only two which had a benzyl group at position R'were weakly mutagenic to Salmonella typhimurium TA100, a base-pair substitution strain, with metabolic activation by S-9 mix. On the contrary, 6 carbamate type N-nitroso compounds which had an alkoxy or benzyloxy group at position R showed considerable mutagenic activity for TA100 with metabolic activation. Two of the carbamate type compounds which had a benzyl group at position R'were also mutagenic in Salmonella typhimurium TA98, a frameshift strain, even without metabolic activation.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 29 (6), 1758-1762, 1981
公益社団法人 日本薬学会
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詳細情報
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- CRID
- 1390282679139370240
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- NII論文ID
- 110003633893
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- PubMed
- 7296724
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可