Stereoisomeric alanine peptides as substrates for human spleen fibrinolytic proteinase (SFP).

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Four kinds of stereoisomeric Z-Ala-Ala-OMe and eight kinds of stereoisomeric Z-Ala-Ala-Ala-OMe were tested as substrates for human spleen fibrinolytic proteinase (SFP) in comparison with porcine pancreatic elastase. Both enzymes exhibited esterase activity towards not only Z-L-Ala-L-Ala-L-Ala-OMe (VI) but also Z-D-Ala-L-Ala-L-Ala-OMe (VII). The rate of esterolysis of VI by elastase was only about twice the rate of esterolysis by SFP although the rate of amidolysis of Suc-L-Ala-L-Ala-L-Ala-pNA (XVI) by elastase was tenfold faster than that by SFP.

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