Anti-platelet aggregation principles from the bark of Fraxinus japonica Blume.

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The methanol extract of the bark of Fraxinus japonica BLUME was fractionated with the guidance of inhibitory activity on rabbit platelet aggregation induced by arachidonic acid. The following active principles were identified : 3-methoxy-4-hydroxyphenylethanol (I) (which also exists in the animal body as a dopamine metabolite), p-hydroxyphenylethanol (II), 2, 6-dimethoxy-p-benzoquinone (III), compounds (IV), (V), and esculetin.

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