The effects of grinding and drying on the solid state stability of sodium prasterone sulfate.

• 中川 寛

• 高橋 嘉輝

• 杉本 功

抄録

The effects of grinding and drying (removal of water of crystallization) processes on the solid state stability of sodium prasterone sulfate (DHA·SO₃Na·2H₂O) were studied. As the grinding time was increased, the sample became more unstable. From the study of the thermal behavior of the water of crystallization, it was suggested that the bonding force between the water of crystallization and DHA·SO₃Na molecule within the hydrate crystal was weakened by grinding, and water molecules participated in the hydrolysis of DHA·SO₃Na more easily. Although DHA·SO₃Na was found to be hydrolyzed, the ground DHA·SO₃Na·2H₂O was more stable under conditions of high humidity than low humidity. This result is very interesting, and it was considered that the bonding force between the water of crystallization and DHA·SO₃Na molecule was strengthened in conditions of high humidity. The dehydration of DHA·SO₃Na·2H₂O resulted in a higher disorder of the crystal structure and water molecules were sufficiently free to participate in a solid state hydrolytic reaction. Therefore, partially dehydrated DHA·SO₃Na·2H₂O decomposed easily. After almost complete removal of the water of crystallization, the sample was relatively stable, since it contained few water molecules which could participate in hydrolysis. The dihydrate form was the most stable.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 30 (1), 242-248, 1982

  公益社団法人 日本薬学会

キーワード

• water of crystallization

詳細情報

• CRID: 1390282679139664896
• NII論文ID: 110003634085
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.30.242
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 6211259
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/30/1/30_1_242/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1982210801
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可